How Does Amitiza Work?

In a Nutshell

Amizita, manufactured by Sucampo Pharma Americas, Inc, is approved by the FDA for the treatment of chronic idiopathic constipation and Irritable Bowel Syndrome (IBS) in adult women. Idiopathic constipation refers to a condition where the cause of constipation is unknown. The manufacturer warns that the medication is not suitable for patients with bowel blockage.

The active ingredient in Amizita, lubiprostone, is a complex organic acid that acts on cells in the intestine to promote the mobility of stool through the organ by increasing the amount of fluid available to the intestine.

Activating Channels

According to the manufacturer, lubiprostone acts on local chloride channels in the cells of the intestines. The ingredient specifically activates a chloride channel called ClC-2, found in the apical membrane of the intestine.

Greasing the Passage

The activation of ClC-2 in the intestinal epithelium promotes the secretion of chloride-rich intestinal fluid into the organ. The additional fluid facilitates the movement of stool through the intestines.